Rheum4Science - T Cells - What Every Rheumatologist Needs to Know
Basic and Clinical Sciences
Sunday, May 1, 2022, 12:00 AM
Wednesday, December 31, 2025, 11:55 PM
Fellows in Training, Residents, Rheumatologists

Activity Information

Rheumatologists need a solid understanding of the immune system in order to understand the pathology of rheumatic diseases and drug mechanisms of action. The creation of Rheum4Science grew out of the conviction that the teaching of science is declining in rheumatology. Rheum4Science is designed to teach the underlying biology and clinical research methodology necessary for the knowledgeable practice of rheumatology. This basic and clinical science curriculum is designed as a series of online case-based activities that can be used by trainees or practitioners working independently or with a faculty mentor.

Target Audience

Rheum4Science activities are targeted to rheumatology fellows in training, but the program could also be used by medical students, residents, practicing rheumatologists, and other rheumatology health care providers (ACR/ARP members) interested in strengthening their understanding of basic scientific principles and clinical research methodology relevant to the field of rheumatology.

Learning Objectives

Upon completion of this activity, participants should be able to do the following:

  • Describe the components of T cell antigen receptor
  • Compare antigen presentation to CD4 vs. CD8 T cells
  • Review steps in lymphocyte activation and differentiation
  • Describe major T cell subsets:
    • Define different TH subsets and their functions
    • Review inducing agents, effectors and applicable therapies for different CD4 subsets

Registration Info

Click Enroll to register for this Rheum4Science activity a la carte, or click here to register for the full curriculum.

Registration is complimentary.


The ACR acknowledges the contributions of the members of the Rheum4Science Working Group, who identified the need for these resources, developed the curriculum, and brought its earliest activities to fruition.

Juliet Aizer, MD, MPH; Anne R. Bass, MD; Leonard Calabrese, DO; Lisa Mandl, MD, MPH; Bethany Marston, MD; Michael H. Pillinger, MD; William Rigby, MD; Christopher T. Ritchlin, MD, MPH; Gregg Silverman, MD

The ACR also recognizes the following faculty for providing expert reviews, ensuring content accuracy and relevancy.

Jessica Gordon, MD, MSc; Justin Levinson, MD, MBA; Bethany Marston, MD; Yair Molad, MD