Rheum4Science: Complement Pathways
Activity Overview
The creation of the Rheum4Science program grew out of the conviction that teaching science is important for rheumatologists in training and that adult learners benefit from a variety of resources and formats. Rheum4Science interactive modules teach the underlying immunology and clinical research methodology necessary for the knowledgeable practice of rheumatology.
Complement activation is essential for human survival. Complement abnormalities of under- and over-activation have multiple adverse effects on inflammation and immunity. This activity reviews the pathways of complement activation, its normal functional roles, and some key aspects of complement abnormalities that contribute to human disease.
Rheum4Science Series
This activity is part of a series. See the other activities in the series below.
Rheum4Science – Immunology
- Rheum4Science: Overview of Innate Immunity
- Rheum4Science: Toll-Like Receptors
- Rheum4Science: The NLRP3 Inflammasome
- Rheum4Science: Complement Pathways
- Rheum4Science: Fundamental Principles of B Cell Immunobiology
- Rheum4Science: T Cells - What Every Rheumatologist Needs to Know
- Rheum4Science: Neutrophils
Rheum4Science – Immunopathogenesis of Rheumatic Disease
Rheum4Science – Clinical Research Methodology
- Rheum4Science: Data & Distribution
- Rheum4Science: Cohort Studies
- Rheum4Science: Randomized Controlled Trials
Registration is complimentary.
Target Audience
Rheumatology fellows in training. This activity
may also be of interest to medical students, residents, practicing
rheumatologists, and other rheumatology health care providers interested in
strengthening their understanding of basic scientific principles and clinical
research methodology relevant to the field of rheumatology.
Learning Objectives
Upon completion of this activity, participants should be able to:
- Compare the three complement pathways – understand how their unique and shared components function in normal immune response.
- Describe the effects of complement activation on innate and adaptive immunity in both normal and pathologic states.
- Discuss consequences of complement component deficiencies, including associations with known diseases.
- Explain how complement pathways are regulated and give examples of disorders that arise from regulatory dysfunction.
CE & MOC Information
This activity is not eligible for CME/MOC.
