The creation of the Rheum4Science program grew out of the conviction that teaching science is important for rheumatologists in training and that adult learners benefit from a variety of resources and formats. The Rheum4Science: Immunology Series provides a progressive, clinically focused foundation in immunology for emerging rheumatology clinicians.Participants will explore innate and adaptive immune mechanisms and their relevance to rheumatologic disease, strengthening diagnostic insight and clinical decision‑making.Rheum4Science SeriesThis activity is part of a series. See the other activities in the series below.Rheum4Science: Immunology SeriesRheum4Science: Pathology SeriesRheum4Science Interactive ModulesRheum4Science – Clinical Research MethodologyRheum4Science: Data & DistributionRheum4Science: Cohort StudiesRheum4Science: Randomized Controlled TrialsRheum4Science – Immunopathogenesis of Rheumatic DiseaseRheum4Science: Pathogenesis of Rheumatoid ArthritisRegistration is complimentary.Target AudienceRheumatology fellows in training. This activity may also be of interest to medical students, residents, practicing rheumatologists, and other rheumatology health care professionals interested in strengthening their understanding of basic scientific principles and clinical research methodology relevant to the field of rheumatology. Learning ObjectivesUpon completion of this activity, participants should be able to: Explain the core organization and principles of the immune system, including recognition, activation, regulation, and memory in health and diseaseDifferentiate innate and adaptive immune responses, including their key cells, mediators, effector mechanisms, and timingDescribe how immune responses are initiated and shaped, including pattern recognition, antigen processing and presentation, and immune signaling pathwaysSummarize the roles of key immune cells and mediators, including dendritic cells, neutrophils, cytokines, complement, T cells, B cells, and antibodiesExplain how immune responses are anatomically organized, including lymphoid organs, immune compartments, and cellular traffickingRecognize mechanisms of immune dysregulation that contribute to autoimmunity, autoinflammatory disease, and immune‑mediated tissue injuryApply foundational immunologic concepts to clinical reasoning in rheumatology, supporting diagnostic interpretation and therapeutic decision‑makingCE & MOC InformationThis activity is not eligible for CE/MOC.Acknowledgement of Commercial SupportNo commercial support was provided for this activity.Educational Activity PoliciesSee ACR educational activity policies, including the online enduring activity refund policy.