Activity OverviewThe creation of the Rheum4Science program grew out of the conviction that teaching science is important for rheumatologists in training and that adult learners benefit from a variety of resources and formats. Rheum4Science interactive modules teach the underlying immunology and clinical research methodology necessary for the knowledgeable practice of rheumatology. In this activity, learn all about Toll-Like Receptors (TLRs) and their role in chronic inflammation in rheumatic diseases. Rheum4Science SeriesThis activity is part of a series. See the other activities in the series below.Rheum4Science – ImmunologyRheum4Science: Overview of Innate ImmunityRheum4Science: Toll-Like ReceptorsRheum4Science: The NLRP3 InflammasomeRheum4Science: Complement PathwaysRheum4Science: Fundamental Principles of B Cell ImmunobiologyRheum4Science: T Cells - What Every Rheumatologist Needs to KnowRheum4Science: NeutrophilsRheum4Science – Immunopathogenesis of Rheumatic DiseaseRheum4Science: Pathogenesis of Rheumatoid ArthritisRheum4Science – Clinical Research MethodologyRheum4Science: Data & DistributionRheum4Science: Cohort StudiesRheum4Science: Randomized Controlled Trials Registration is complimentary.Target AudienceRheumatology fellows in training. This activity may also be of interest to medical students, residents, practicing rheumatologists, and other rheumatology health care providers interested in strengthening their understanding of basic scientific principles and clinical research methodology relevant to the field of rheumatology. Learning ObjectivesUpon completion of this activity, participants should be able to:Define the purpose and core features of the innate immune responseRecognize major components of the innate immune system and define their functionsIdentify important receptors of the innate immune system and recognize how innate immunity is triggered in response to infection or dangerDifferentiate innate and adaptive immune responses and describe the connection between innate and adaptive immunityCE & MOC InformationThis activity is not eligible for CME/MOC.Acknowledgement of Commercial SupportNo commercial support was provided for this activity.Educational Activity PoliciesSee ACR educational activity policies, including the online enduring activity refund policy.