Activity OverviewThe creation of the Rheum4Science program grew out of the conviction that teaching science is important for rheumatologists in training and that adult learners benefit from a variety of resources and formats. Rheum4Science interactive modules teach the underlying immunology and clinical research methodology necessary for the knowledgeable practice of rheumatology. This activity covers the biology and clinical research methodology of T-cell antigen, subsets, and TH subsets and their functions. Rheum4Science SeriesThis activity is part of a series. See the other activities in the series below.Rheum4Science – Immunology Rheum4Science: Overview of Innate Immunity Rheum4Science: Toll-Like Receptors Rheum4Science: The NLRP3 Inflammasome Rheum4Science: Complement Pathways Rheum4Science: Fundamental Principles of B Cell Immunobiology Rheum4Science: T Cells - What Every Rheumatologist Needs to Know Rheum4Science: Neutrophils Rheum4Science – Immunopathogenesis of Rheumatic Disease Rheum4Science: Pathogenesis of Rheumatoid Arthritis Rheum4Science – Clinical Research Methodology Rheum4Science: Data & Distribution Rheum4Science: Cohort Studies Rheum4Science: Randomized Controlled TrialsRegistration is complimentary. Target AudienceRheumatology fellows in training. This activity may also be of interest to medical students, residents, practicing rheumatologists, and other rheumatology health care providers interested in strengthening their understanding of basic scientific principles and clinical research methodology relevant to the field of rheumatology. Learning ObjectivesUpon completion of this activity, participants should be able to:Describe the components of T cell antigen receptorCompare antigen presentation to CD4 vs. CD8 T cellsReview steps in lymphocyte activation and differentiationDescribe major T cell subsets: o   Define different TH subsets and their functions. o   Review inducing agents, effectors and applicable therapies for different CD4 subsets.CE & MOC InformationThis activity is not eligible for CME/MOC.Acknowledgement of Commercial SupportNo commercial support was provided for this activity.Educational Activity PoliciesSee ACR educational activity policies, including the online enduring activity refund policy.