Rheum4Science: All Activities
R4S-ALL-EXP23
Basic and Clinical Sciences, Rheumatoid Arthritis
Rheum4Science
Friday, September 1, 2017, 12:00 AM
Thursday, May 1, 2025, 12:00 AM
Participation
Rheumatologists, Fellows in Training, Residents

Program Information

Rheumatologists need a solid understanding of the immune system in order to understand the pathology of rheumatic diseases and drug mechanisms of action. The creation of Rheum4Science grew out of the conviction that the teaching of science is declining in rheumatology. Rheum4Science is designed to teach the underlying biology and clinical research methodology necessary for the knowledgeable practice of rheumatology. This basic and clinical science curriculum is designed as a series of online case-based activities that can be used by trainees or practitioners working independently or with a faculty mentor.


Target Audience

Rheum4Science activities are targeted to rheumatology fellows in training, but the program could also be used by medical students, residents, practicing rheumatologists, and other rheumatology health care providers (ACR/ARP members) interested in strengthening their understanding of basic scientific principles and clinical research methodology relevant to the field of rheumatology.


How to Use Rheum4Science

Rheum4Science activities are targeted to rheumatology fellows in training, medical students, residents, practicing rheumatologists, and other rheumatology health care providers interested in strengthening their understanding of basic scientific principles and clinical research methodology relevant to the field of rheumatology.

Each activity is a standalone that can be completed as a self-study activity or in small groups. Learners may benefit from discussion of key takeaways and questions in a group after completion.


Registration

Registration is complimentary.


Rheum4Science Activities

  • Activity 1 - Overview of Innate Immunity
  • Activity 2 - Toll-Like Receptors in Rheumatic Disease
  • Activity 3 - The NLRP3 Inflammasome
  • Activity 4 - Data and Distributions
  • Activity 5 - Cohort Studies
  • Activity 6 - Pathogenesis of Rheumatoid Arthritis
  • Activity 7 - Randomized Controlled Trials
  • Activity 8 - Neutrophils
  • Activity 9 - T Cells: What Every Rheumatology Needs to Know


Activity Authors

Activity 1 - Overview of Innate Immunity
Leonard Calabrese, DO; Bethany Marston, MD

Activity 2 - Toll-Like Receptors in Rheumatic Disease
Bethany Marston, MD; Christopher T. Ritchlin, MD, MPH

Activity 3 - The NLRP3 Inflammasome
Bethany Marston, MD; Michael H. Pillinger, MD

Activity 4 - Data and Distributions
Juliet Aizer, MD, MPH; Marianna B. Frey, BA; Lisa A. Mandl, MD, MPH; Noa Schwartz, MD, MS

Activity 5 - Cohort Studies
Juliet Aizer, MD, MPH; Lisa A. Mandl, MD, MPH

Activity 6 - Pathogenesis of Rheumatoid Arthritis
William Rigby, MD

Activity 7 - Randomized Controlled Trials
Juliet Aizer, MD, MPH; Lisa A. Mandl, MD, MPH; Diane Zisa, MD

Activity 8 - Neutrophils
Ruth Fernandez-Ruiz, MD, MSCI; Michael H. Pillinger, MD

Activity 9 - T Cells: What Every Rheumatologist Needs to Know
R. John Looney, MD


Acknowledgments

The ACR acknowledges the contributions of the members of the Rheum4Science Working Group, who identified the need for these resources, developed the curriculum, and brought its earliest activities to fruition.

Juliet Aizer, MD, MPH; Anne R. Bass, MD; Leonard Calabrese, DO; Lisa Mandl, MD, MPH; Bethany Marston, MD; Michael H. Pillinger, MD; William Rigby, MD; Christopher T. Ritchlin, MD, MPH; Gregg Silverman, MD

The ACR also recognizes the following faculty for providing expert reviews, ensuring content accuracy and relevancy.

Jessica Gordon, MD, MSc; Justin Levinson, MD, MBA; Bethany Marston, MD; Yair Molad, MD

Rheum4Science09: T Cells - What Every Rheumatologist Needs to Know

Rheum4Science T-Cells covers the biology and clinical research methodology of T-cell antigen, subsets, and TH subsets and their functions – all necessary for the knowledgeable practice of rheumatology.

Rheum4Science01: Overview of Innate Immunity

To kick off the series, Rheum4Science’s first activity focuses on the innate immune response, including its essential feature, triggers, elements, and how innate immunity is linked with adaptive immunity.

Rheum4Science02: Toll-Like Receptors in Rheumatic Disease

What is a toll-like receptor (TLR) and what should we know about them? In this activity, you will learn everything you need to know about TLRs and their role in chronic inflammation in rheumatic diseases.

Rheum4Science03: The NLRP3 Inflammasome

The NLRP3 inflammasome is a key player in several rheumatic diseases, so understanding its structure and function will serve students, residents, practicing rheumatologists, and health care providers well.

Rheum4Science04: Data & Distributions

The next activity in the Rheum4Science series is all about data collection and distribution. Learn the different variables and select and interpret the best measures of central tendency and dispersion.

Rheum4Science05: Cohort Studies

In the fifth activity of the series, you will receive a comprehensive guide to cohort studies - from defining strengths and limitations to applying the results of a cohort study to patient scenarios.

Rheum4Science06: Pathogenesis of Rheumatoid Arthritis

For further understanding of the pathogenesis of rheumatoid arthritis (RA), this next activity will help you identify the immune components of preclinical RA and the implications for treatment of RA.

Rheum4Science07: Randomized Controlled Trials

Randomized controlled trials (RCT) are an integral part of assessing efficacy. In this activity, you will learn when an RCT is appropriate, whether to trust the results, and how to interpret the results.

Rheum4Science08: Neutrophils

Learn to identify the subcellular structure of neutrophils, review their function and role in inflammation, as well as recognize the neutrophil targets of commonly used antirheumatic drugs in this activity.